Histocompatibility Antigens Class I

Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

Also Known As:

Class I Histocompatibility Antigens; Class I Human Antigens; Class I MHC Proteins; Class I Major Histocompatibility Antigens; Class I Major Histocompatibility Molecules; Human Class I Antigens; MHC Class I Molecules; MHC-I Molecules; MHC-I Peptides; Antigen, Class I; Antigens, Class I; I Antigen, Class; MHC I Molecules; MHC I Peptide; MHC I Peptides; Molecules, MHC-I; Peptide, MHC-I; Peptides, MHC-I; Class I Antigen; Class I Antigens; Class I Histocompatibility Antigen; Class I MHC Protein; Class I Major Histocompatibility Antigen; MHC Class I Molecule; MHC-I Peptide

Carbohydrates: 22516
- Glycoconjugates: 1370
  - Glycoproteins: 25180
    - Membrane Glycoproteins: 2277
      - Histocompatibility Antigens Class I: 1938
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Glycoproteins: 25180
    - Membrane Glycoproteins: 2277
      - Histocompatibility Antigens Class I: 1938
  - Membrane Proteins: 10262
    - Membrane Glycoproteins: 2277
      - Histocompatibility Antigens Class I: 1938
Biological Factors: 2560
- Antigens: 145631
  - Surface Antigens: 5857
    - Histocompatibility Antigens: 1126
      - Histocompatibility Antigens Class I: 1938
  - Isoantigens: 1219
    - Histocompatibility Antigens: 1126
      - Histocompatibility Antigens Class I: 1938

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Disease

Drug/Important Bio-Agent (IBA)